Development and evaluation of ibuprofen transdermal gel. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to. We are committed to maintaining the highest level of quality. Nov 03, 2016 the blank formulation did not contain any active ingredients or any preservative. Abstract gel formulation provides better application property and stability in comparison to cream and ointment.
A brilliant, clear hair gel that provides hold without sacrificing flexibility. Kanwal1, ahmad 1nawaz1, amna shah1 and ghulam murtaza. Pdf formulation and evaluation of hair gel for the. Formulation and evaluation of mefenamic acid emulgel for. The measurement was performed at 1, 30, 60, 90 days. Optimized formulation m5 showed drug release of 71% in 6 hours, particle size of 88.
Formulation and evaluation of diclofenac transdermal gel malla reddy college of pharmacy, permeation study using rat abdominal skin. They exhibit maximal chemical instability they adopt multiple conformers they tend to selfassociate they can exhibit complex physical instabilities, such as gel formation chemical instability the most common chemical degradation mechanisms for peptide and protein degradation are deamidation and oxidation 1. The above formulation should be clear when diluted 10 parts with 90 parts diesel. Formulation and evaluation of herbal hair gel for hair growth potential t regupathi1, k chitra2, k ruckmani3, kg lalitha4 and mohan kumar3 1department of pharmaceutics, ultra college of pharmacy, india 2department of pharmaceutical chemistry, sri ramachandra university, india 3department of pharmaceutical technology, bit campus anna university. Formulation and evaluation of gel containing econazole nitrate request pdf. Reduced risk of penetration into eyes due to gel form. The odor of prepared formulations was good acceptable which is desirable as cosmetic formulations. All gels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability and ph value. Clotrimazole is an imidazole derivative with a broad spectrum anti. Gel formulation in the study was made from a mixture of carrageenan and sodium benzoate in distilled water at a temperature of 75oc and then added patchouli and citrus essential oil with a variety of different concentrations of 1%, 2% and 3%, then performed an evaluation form. No zone of inhibition was observed for the blank, paraben, and 0.
The gel phase in the formulations was prepared by dispersing carbopol 940 in purified water with constant stirring at a moderate speed using mechanical shaker, then the ph was adjusted to 66. University of patanjali haridwar, uttarakhand 249402 2. The other slide was placed on the top of the gel, such that the gel was sandwiched between the two slides in an area occupied by a distance of 6. The gel was prepared from carbopol and 5% of borneol. Evaluation and selection of gel base for the formulation of. Micellar gel for facial cleansing, pegfree ul 58039. A recent approach for novel drug delivery loveleen preet kaur, tarun kumar guleri department of pharmaceutics, sri sai college of pharmacy, pathankot, punjab state, india. Natpure xtra longevity green tea stimulates the skins defense against oxidative stress to maintain youthful looking skin. Development and evaluation of stability of a gel formulation. Formulation, evaluation and antibacterial efficiency of water.
Pdf the present investigation involves formulation of acelofenac topical gel having linseed oil and piparine. Formulation and evaluation of topical gel using eupatorium. The present research work deals with use of ethanolic extracts of garlic, aloe vera and neem in formulation and evaluation of anti acne gel. Cosmetic formulation basics styling gel chemists corner. Research article formulation and evaluation of gel and emulgel of chili extract capsicum frutescens l. This collection of guideline formulation examples provides an overview of how the wide range of sasol raw materials can be used to fulfil your performance and formulation requirements. Therefore, a 14 day beyonduse date should be assigned. Carbopol 934 p, hydroxypropylmethylcellulose hpmc, gelatin, sodium alginate, sodium carboxymethylcellulose cmc and its comparison with marketed gel formulation. Gel formulation provides better application property and stability in comparison to cream and ointment. Pdf formulation and evaluation of topical nano emulgel of. Introduction topical gel is a localized drug delivery system, skin.
The gel formulation was placed over one of the slides. Our hair care formulations are backed by dsms decades of expertise and therefore include polymers alongside uv filters, skin bioactives and vitamins. Pdf formulation of mefenamic acid loaded ethosomal gel. Development and evaluation of ibuprofen transdermal gel formulations bazigha k abdul rasool 1, eman f abugharbieh 1, sahar a fahmy 2, heyam s saad 1 and saeed a khan 1 1dubai pharmacy college, dubai, uae, 2helwan university, helwan, egypt abstract purpose. Hand sanitizer gel having important ingredients that are ethyl alcohol or isopropyl alcohol or together used in the same mixture,carbomer used for thickness, glycerine to protect hand outside,preservative agent to protect products etc. The optimised cubosome formulation m5 was used for the miconazole nitrate gel using carbopol 934, carbopol 940, hpmc k4m, hpmck15m and studied for ph, viscosity, in. A gel is a solid or semisolid system of at least two constituents, consisting of a condensed mass enclosing and interpenetrated by a liquid. Then the formulations underwent macroscopic and microscopic studies. The aim of the present research work is to decrease the systemic side effects and to create a more pronounced effect of nano emulgel of adapalene with lower doses of the drug. A 5% dilution of the diesel solution in water should yield a stable emulsion. Manufacturing process of ultrasound gel is not very complicated. Formulation of hair tonic and gel preparations were made using 7. To develop an ibuprofen transdermal gel with a capability for both topical and systemic. Whether you want to excite consumers with new hair care products or skin cleansers, improve performance in sunscreens or antiperspirants, or develop environmentallyfriendly solutions, we have the technologies and expertise you need.
Results suggest that proniosomal gel can enhance delivery of diclofenac through skin and can improve the bioavailability of drug. Elaborated sensory assessment from dsms panel of sensory experts stimulates the development of formulations that. Hydrogel, dexpanthenol, carboxyvinyl polymers, gels, carbopol, poloxamer, rheology, drug release, penetrometer. Transparent shower gel with avocado and jojoba oil 17 water free shower oil with soya, castor and jojoba oil 18. The aim of the present study is the formulation of mefenamic acid ethosomal gel by hot and cold methods.
Formulation and in vitro evaluation of carbopol 934based. The gel formulations were evaluated for physical appearance, drug release and stability. The topical gel formulation offers an interesting alternative for achieving systemic drug effects of parental routes, which can be inconvenient for oral route, which can result in nausea, vomiting, low bioavailability and passes the hepatic firstpass metabolism. Formulation and evaluation of topical gel authorstream.
This publication or anything contained within this publication is intended for informational purposes only. Formulation and evaluation of antibacterial creams and. Gel formulations prepared with carbopol 934, hpmc k 100 m and xanthan gum showed good homogeneity, no skin irritation, good stability and anti. Topical antiinflammatory activity of gel was also evaluated. For the production, there is need usable and tried a formulation, raw materials and mixing tank. Every cosmetic chemist should learn how to make a gel. It has a great look and consumers respond well to the product form. Ingredients can be combined to create hybrid formulations that style, protect and provide care, so consumers get a product that fits in with their individual lifestyle and need.
From the literature, the formulation with hec gel base exhibited better properties for topical delivery of drugs when compared with the other formulations 3, 4. To formulate topical gels containing various essential oils and evaluate their antibacterial activity against. The stability study of optimized formulation was also done. We hope to inspire new ideas by providing examples of formulation concepts and guideline formulations. Formulation and evaluation of curcumin gel for topical. Approximately 18% alcohol usp will preserve a formulation. Formulations and manufacturing process of phenyl, naphthalene ball, mosquito coil, floor. Clay based or earth based ready to use or dry powder present research article deals with the formulation and evaluation of cosmetic herbal face pack for glowing skin at home by using natural materials i. Gel serums impart that tightening feeling on the skin and allow your customer to feel that their skin is being temporarily lifted or tightened in certain areas of the face. To prepare the mefenamic acid transdermal gel, ethosomes was selected as colloidal carriers. Topical gel, precutaneous absorption, emulgel, hydrogel. A mouth ulcer is a break or breach in the mucous membrane, which is lines the inside of the mouth.
Topical gel formulations provide a suitable delivery system for drugs because they are less greasy and can be easily removed from the. The optimized formulation was found to be f5 containing medium concentration of span 60 50 mg and medium concentration of cholesterol 250 mg. Ftir stu introduction the transdermal drug delivery systems are selfcontained, discrete dosage forms which when applied to intact skin deliver the drug through the skin at a. The most common type of gel in the cosmetic industry is hair styling gels so well explain how they work and how to make them. Bath gel bubblebath gel blooming bath oil bath and shower gel bubble bath premium foam bath.
Hec formulation was developed and in vitro transdermal penetration of this formulation was compared with that commercial vurdon gel 1% help. The preparation of emulsion was same in all the formulations. Formulation and evaluation of herbal hair gel for hair growth. As topical dosage forms effionora anwar, delly ramadon, harmita faculty of pharmacy, kampus ui depok, 16424, indonesia. Formulation f5 with 1 % leaves extract and f11 with 1% root extract of clerodendrum serratum showed the best formulation with significant antiinflammatory. This formula contains plenty of natural ingredients and is fragrancefree. A gel is a solid, jellylike material that can have properties ranging from soft and weak to hard and tough. Building on our strong expertise in application, dsm formulators create desirable formulations that can be used in a variety of market applications. Formulation, evaluation and antibacterial efficiency of waterbased herbal hand sanitizer gel shri balakrishna acharya 1, saradindu ghosh2, giriraj yadav3, kavita sharma2, dr. Delivery of drugs to the skin is an effective and targeted therapy for local dermatological disorders. Nanoemulsion and nanoemulgel as a topical formulation. The formulation named paraben contained preservative but no active ingredients. The prepared formulation was subjected to physical characterization and physicalchemistry assessment. However, there is no reference that provides stability studies for this formulation.
Formulation and in vitro evaluation of carbopol 934based modified clotrimazole gel for topical application muhammad ubaid1, sadaf ilyas1, sadullah mir2, abida k. To this solution was added slowly lutrol f 127, continuously. Evaluation of topical gel formulation physical parameters such as color, appearance, homogeneity and grittiness were inspected through visual inspection. Formulation f1, f2 and f4 were slightly yellow in color and formulation f3 showed as greenish yellow. Spreadability of semisolid formulations, that is, the ability of a cream or gel to evenly spread on the skin, plays an important role in the administration of a standard dose of a medicated formulation to the skin and the efficacy of a topical therapy. At present, there are number of antifungal agents use topical applications like clotrimazole, griseofulvin, itraconazole, fluconazole etc. This soothing aloe serum may help calming freshly stressed skin.
Department of pharmaceutics and industrial pharmacy, faculty of pharmacy, modern university for technology and info rmation, cairo. Formulation and evaluation of topical herbal gel for the. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. Evaluation of topical gel bases formulated with various essential. Gels containing aloe vera juice extract and sodium cmc showed phase separation and were rejected. The gel formulation was designed by using methanolic extract of leaves of c alata and c tora and aerial part of c. Formulated with our highly concentrated botanical active, natpure xtra, powered by phytoclean process. The reference gives a beyonduse date of 1 year, but the warning of periodically observing the formulation for signs of physical instability. For raw materials to be used, quantities to be used and ingredients usage rankings, you should look into this formulation. Thus cosmetics is the art of decorating yourself to look beautiful.
The particle size of formulations was in the range of 22. Measurement of ph ph of the gel was measured by using ph meter. One of the most common disorders found among youngsters usually 18 25 years of age is acne. However, the published material is being distributed without warranty of any kind, either expressed or implied. There is a remarkable demand of herbal formulations in the global market. Formulation and evaluation of polyherbal antiacne gel fatima grace x, joan vijetha r, rahul raj s, shanthi s, latha s, shanmuganathan s faculty of pharmacy, sri ramachandra university, porur, chennai, tamil nadu, india abstract aim. Formulation and evaluation of diclofenac transdermal gel. Uses of topical gel preparations are for skin application or percutaneous penetration of medicament or local action to certain mucosal surfaces singh, 2014. Formulation development, optimization and evaluation of aloe. Because this formulation is waterbased, the gel serum gives you the opportunity to incorporate some wonderful waterbased hydrophilic botanical extracts. Nano emulgel emerged as one of the most interesting topical drug delivery. Automatic dishwasher detergentdry mix formulation automatic dishwasher detergentagglomerated formulation. Formulation and evaluation of topical aceclofenac gel using.
Twelve herbal gel formulations were prepared using 1. Deionized water peg150 distearate hallstar 6000 ds bioterge as40 or bioterge as40 hp amphosol cs50 glycerin uniqema dlpanthenol roche panthenol preservative, dye, fragrance citric acid sodium hydroxide sodium. Design, formulation and evaluation of an oral gel from. This formulation will be preserved due to the very high alcohol concentration. Evaluation of gel formulations evaluation parameters of gel formulations are given in table 2 and they are. Several formulations with different amounts of carbomer 934, sodium carboxymethylcellulose scmc and hydroxypropyl methylcellulose k 4 m were prepared and the condensed extract was dispersed in polyethyleneglycol peg 400 and added to gel bases. The drug release from all gelling agents through a standard cellophane membrane was evaluated using. Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model 495 quality control of topical herbal gel formulation estimation of active constituents in gel formulation net content each formulation 1 g was taken in a 50 ml volumetric flask and made up to volume with methanol and. How to make ultrasound gel ultrasound gel formulation. Whorecommended handrub formulations all reasonable precautions have been taken by the world health organization to verify the information contained in this document. Formulation of lutrol f 127 gel with dexpanthenol dexpanthenol was dissolved in the mixture of lutrol e 400, distilled water and liquid paraffin, then mixed on a water bath at 60 70 oc. Formulation and evaluation of antibacterial creams and gels.
However, the xanthan gum based gel proved to the formula of choice, since it showed the highest percentage of extrudability, good spreadability and rheological properties. The hydrogel made with lutrol f 127 gel base possesses the best properties of all the gels and is recommended for the formulation of a suitable dexpanthenol gel. The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil. The term cosmetics have been derived from the term cosmetikos which means the skill to decorate. At the same time, we have focused on improving the mildness of formulations. Basf offers broad portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for your gel formulation.